Searchlight Pictures has released the first official trailer for “A Real Pain”, which stars Kieran Culkin and Jesse Eisenberg.

The comedy drama is written and directed by Eisenberg and premiered at Sundance earlier this year, where Eisenberg won the Waldo Salt Screenwriting Award.

The film follows mismatched cousins David and Benji (Eisenberg and Culkin) who reunite for a tour through Poland to honor their beloved grandmother. The adventure takes a turn when the pair’s old tensions resurface against the backdrop of their family history.

Also in the film are Will Sharpe, Jennifer Grey, Kurt Egyiawan, Liza Sadovy, Daniel Oreskes and Ellora Torchia.

“A Real Pain” is set to premiere on October 18 in theaters.